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ProductSafetyAssessmentPropyleneOxideProductSafetyAssessmentdocumentsareavailableatwww.dow.com/productsafety/assess/finder.®TMTrademarkoftheDowChemicalCompany(“Dow”)oranaffiliatedcompanyofDowRevised:May31,2013TheDowChemicalCompanyPage1of7SelectaTopic:NamesProductOverviewManufactureofProductProductDescriptionProductUsesExposurePotentialHealthInformationEnvironmentalInformationPhysicalHazardInformationRegulatoryInformationAdditionalInformationReferencesNamesCASNo.75-56-9PropyleneoxidePropeneoxideAlkylepoxide1,2-propyleneoxidePropeneepoxide1,2-epoxypropaneEpoxypropaneMethylethyleneoxideMethyloxirane2-methyloxiraneBacktotopProductOverviewPropyleneoxideisacolorless,low-boiling,highlyvolatileliquidwithasweet,ether-likesmell.Itishighlyflammableandreactive.1Forfurtherdetails,seeProductDescription.Propyleneoxideisachemicalintermediateusedtomakeawiderangeofindustrialandconsumerproducts.Itisamongthetop50chemicalsproduced(byvolume)intheworld.About60%ofthepropyleneoxideproducedannuallybyDowisusedtomanufacturepolyetherpolyols,amajorcomponentofpolyurethanefoam.Propyleneoxideisalsoanintermediateinthemanufactureofcosmetics,pharmaceuticals,householddetergents,textiles,andmanyotherproducts.2,3Forfurtherdetails,seeProductUses.Exposurecanoccureitherinafacilitythatmanufacturespropyleneoxideorinthevariousindustrialormanufacturingfacilitiesthatusepropyleneoxide.4Dowdoesnotsellpropyleneoxideforconsumeruse,sodirectconsumercontactwiththisproductisunlikely.Forfurtherdetails,seeExposurePotential.Eyecontactwithliquidmaycausesevereirritationwithcornealinjury,whichmayresultinpermanentimpairmentofvision,evenblindness.Prolongedskincontactisnotlikelytocausesignificantirritationunlesstheproductisconfinedunderclothingorgloves.Prolongedexcessiveinhalationmaycauseseriousadverseeffects,evendeath.Becauseexposedanimalsdevelopedtumorsinlong-termtesting,mostagenciesnowregardpropyleneoxideasapossibleorprobablehumancarcinogen.5,6,7Forfurtherdetails,seeHealthInformation.Propyleneoxideisreadilybiodegradableandphotodegradesrapidlyintheatmosphere.Itisnotlikelytobioconcentrateandrangesfromnontoxictoslightlytoxictoaquaticorganisms.8Forfurtherdetails,seeEnvironmentalInformation.Propyleneoxideliquidandvaporarehighlyflammable.Vaporsmaytravellongdistances,accumulateinlow-lyingareas,andcauseaflashfireorexplosion.Avoidexposuretosourcesofignition.9Forfurtherdetails,seePhysicalHazardInformation.BacktotopProductSafetyAssessment:PropyleneOxide®TMTrademarkoftheDowChemicalCompany(“Dow”)oranaffiliatedcompanyofDowRevised:May31,2013ManufactureofProduct10Capacity–In2012,TheDowChemicalCompanyanditsglobalaffiliatesproducepounds)ofpropyleneoxide,representingabout2propyleneoxideatfacilitiesaroundtheworld,U.S.A.;Stade,Germany;Antwerp,Belgium;MapTaPhut,Thailand;Process–ThetwomanufacturingprocessesusedbyDowtoproducepropyleneoxidecommerciallyarethechlorohydrinprocessandthehydroperoxideprocess.Inthechlorohydrchlorohydrin,whichissubsequentlyreactedwithsodiumorcalciumhydroxidetoformpropyleneoxideandsodiumorcalciumchloride.Inthehydroperoxideprocess,propylenereactswisignificantco-products.Thetworeactionsequencesareshownbelow.BacktotopProductDescription11Propyleneoxideisacolorless,low-boilingandhighlyvolatileliquidwithasweetetherPropyleneoxidereactsreadilywithalcohols,amines,andacids.Propyleneoxidealsorea...