Page1of51HealthandSafetyExecutiveWorkingsafelywithresearchanimals:ManagementofinfectionrisksThisisafree-to-download,web-friendlyversionofWorkingsafelywithresearchanimals:Managementofinfectionrisks(Firstedition,published1997).ThisversionhasbeenadaptedforonlineusefromHSE’scurrentprintedversion.ISBN9780717613779Price£7.95Themainfocusofthisguidanceisworkingsafelywithexperimentallyinfectedanimalsinthelaboratorysetting.Althoughtheguidanceisaimedprimarilyatprotectinghumanhealth,fullaccountistakenofanimalwelfareissues.SincetheACDPfirstpublishedguidanceonanimalcontainment,COSHHregulationshavebeenamended.Thishasresultedinmanyofthebasiccontainmentmeasuresforanimalroomsbeingtranslatedfromguidanceintolaw.ThisnewguidanceamplifiestheprinciplesexpressedinCOSHHandenlargesontherecommendations.HSEBooksPage2of51HealthandSafetyExecutive©Crowncopyright1997Firstpublished1997ISBN9780717613779Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeans(electronic,mechanical,photocopying,recordingorotherwise)withoutthepriorwrittenpermissionofthecopyrightowner.Applicationsforreproductionshouldbemadeinwritingto:TheOfficeofPublicSectorInformation,InformationPolicyTeam,Kew,Richmond,SurreyTW94DUore-mail:licensing@opsi.gov.ukThisguidanceisissuedbytheHealthandSafetyExecutive.Followingtheguidanceisnotcompulsoryandyouarefreetotakeotheraction.Butifyoudofollowtheguidanceyouwillnormallybedoingenoughtocomplywiththelaw.Healthandsafetyinspectorsseektosecurecompliancewiththelawandmayrefertothisguidanceasillustratinggoodpractice.PhotographoncovershowsascanningelectronmicrographofLeptospirainterrogans.Bar=0.5µm.Workingsafelywithresearchanimals:ManagementofinfectionrisksPage3of51HealthandSafetyExecutiveContentsPreface5Background6Introduction6Hazardsandrisk7Controlmeasures-containmentandoperatingprocedures13Introductiontocontainment13Animalcontainmentlevels14AnimalContainmentLevel115AnimalContainmentLevel216AnimalContainmentLevel318AnimalContainmentLevel420Designfeatures22Equipmentforcontainmentandprotection22Operatingprocedures24Decontaminationanddisposalofwaste29Introduction29Decontamination29Disposalofwaste31Testingandvalidationoftreatmentanddisposalmethods32Appendices1Legislationandlocalrules34Healthandsafetylaw34Animalwelfare35Animalhealth36Environmental37Localsafetypoliciesandcodesofpractice372Information,instructionandtraining39Introduction39Trainingforworkwithinfectedanimals403Emergencyprocedures41Cutsandscratches41Spillagesandemergencydecontamination414Geneticmodification44Geneticallymodifiedorganisms(GMOs)44Workwithgeneticallymodifiedmicro-organisms(GMMs)44Workwithgeneticallymodifiedorganisms(GMOs)44Additionalguidance45Deliberaterelease45Workingsafelywithresearchanimals:ManagementofinfectionrisksPage4of51HealthandSafetyExecutive5Containmentofinvertebrates46Bibliography48Furtherinformation51Workingsafelywithresearchanimals:ManagementofinfectionrisksPage5of51HealthandSafetyExecutivePrefaceSincetheAdvisoryCommitteeonDangerousPathogens(ACDP)firstpublishedguidanceonanimalcontainmentintheCategorisationofpathogensaccordingtohazardandcategoriesofcontainmentin1984,1theControlofSubstancesHazardoustoHealthRegulations(COSHH)havebeenamended.Asaresult,manyofthebasiccontainmentmeasuresforanimalroomshavebeentranslatedfromguidanceintolaw.Thisnewguidanceamplifiest...
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