ThisreportcontainsthecollectiveviewsofaninternationalgroupofexpertsanddoesnotnecessarilyrepresentthedecisionsorthestatedpolicyoftheWorldHealthOrganization,theInternationalLabourOrganizationortheUnitedNationsEnvironmentProgramme.HarmonizationProjectDocumentNo.8WHOHUMANHEALTHRISKASSESSMENTTOOLKIT:CHEMICALHAZARDSThisprojectwasconductedwithintheIPCSprojectontheHarmonizationofApproachestotheAssessmentofRiskfromExposuretoChemicals.PublishedunderthejointsponsorshipoftheWorldHealthOrganization,theInternationalLabourOrganizationandtheUnitedNationsEnvironmentProgramme,andproducedwithintheframeworkoftheInter-OrganizationProgrammefortheSoundManagementofChemicals.TheInternationalProgrammeonChemicalSafety(IPCS),establishedin1980,isajointventureoftheUnitedNationsEnvironmentProgramme(UNEP),theInternationalLabourOrganization(ILO)andtheWorldHealthOrganization(WHO).TheoverallobjectivesoftheIPCSaretoestablishthescientificbasisforassessmentoftherisktohumanhealthandtheenvironmentfromexposuretochemicals,throughinternationalpeerreviewprocesses,asaprerequisiteforthepromotionofchemicalsafety,andtoprovidetechnicalassistanceinstrengtheningnationalcapacitiesforthesoundmanagementofchemicals.TheInter-OrganizationProgrammefortheSoundManagementofChemicals(IOMC)wasestablishedin1995byUNEP,ILO,theFoodandAgricultureOrganizationoftheUnitedNations,WHO,theUnitedNationsIndustrialDevelopmentOrganization,theUnitedNationsInstituteforTrainingandResearchandtheOrganisationforEconomicCo-operationandDevelopment(ParticipatingOrganizations),followingrecommendationsmadebythe1992UNConferenceonEnvironmentandDevelopmenttostrengthencooperationandincreasecoordinationinthefieldofchemicalsafety.ThepurposeoftheIOMCistopromotecoordinationofthepoliciesandactivitiespursuedbytheParticipatingOrganizations,jointlyorseparately,toachievethesoundmanagementofchemicalsinrelationtohumanhealthandtheenvironment.WHOLibraryCataloguing-in-PublicationDataWHOhumanhealthriskassessmenttoolkit:chemicalhazards.(IPCSharmonizationprojectdocument;no.8)1.Hazardoussubstances-toxicity.2.Riskassessment.3.Environmentalexposure.4.Toxicology.I.WorldHealthOrganization.II.InternationalProgrammeonChemicalSafety.ISBN9789241548076(NLMClassification:QV600)©WorldHealthOrganization2010Allrightsreserved.PublicationsoftheWorldHealthOrganizationcanbeobtainedfromWHOPress,WorldHealthOrganization,20AvenueAppia,1211Geneva27,Switzerland(tel.:+41227913264;fax:+41227914857;e-mail:bookorders@who.int).RequestsforpermissiontoreproduceortranslateWHOpublications—whetherforsaleorfornon-commercialdistribution—shouldbeaddressedtoWHOPress,attheaboveaddress(fax:+41227914806;e-mail:permissions@who.int).ThedesignationsemployedandthepresentationofthematerialinthispublicationdonotimplytheexpressionofanyopinionwhatsoeveronthepartoftheWorldHealthOrganizationconcerningthelegalstatusofanycountry,territory,cityorareaorofitsauthorities,orconcerningthedelimitationofitsfrontiersorboundaries.Dottedlinesonmapsrepresentapproximateborderlinesforwhichtheremaynotyetbefullagreement.Thementionofspecificcompaniesorofcertainmanufacturers’productsdoesnotimplythattheyareendorsedorrecommendedbytheWorldHealthOrganizationinpreferencetoothersofasimilarnaturethatarenotmentioned.Errorsandomissionsexcepted,thenamesofproprietaryproductsaredistinguishedbyinitialcapitalletters.Allreasonableprecautionshavebeentakenbyth...